Острая лихорадка с тромбоцитопеническим синдромом: заболевание, вызываемое новым флебовирусом

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Вопросы вирусологии. 2017; 62: 60-65

Острая лихорадка с тромбоцитопеническим синдромом: заболевание, вызываемое новым флебовирусом

Сизикова Т. Е., Лебедев В. Н., Пантюхов В. Б., Борисевич С. В.

https://doi.org/10.18821/0507-4088-2017-62-2-60-65

Аннотация

Острая лихорадка с тромбоцитопеническим синдромом (SFTS) - новое инфекционное вирусное заболевание, эндемичное для центральной и северо-восточных частей Китайской Народной Республики. Природным хозяином вируса SFTS, который относится к роду Phlebovirus семейства Bunyaviridae, являются клещи видов Haemaphysalis longicornis и Rhipicephalus microplus. В КНР вирус SFTS обнаружен у многих видов домашних животных, у которых заболевание протекает инаппарантно. Заболевание характеризуется лихорадкой, тромбоцитопенией, лейкоцитопенией, синдромами поражения желудочно-кишечного тракта и нервной системы, проявлениями геморрагического синдрома. Летальность при SFTS составляет от 6 до 30%. Возможна передача вируса от человека к человеку вследствие контакта с кровью больного. В обзоре рассмотрены данные клинического и эпидемиологического изучения инфекции, эволюционный и молекулярно-биологический анализ возбудителя, случаи заболевания за пределами КНР, передача вируса SFTS от человека к человеку, факторы риска при заболевании, вызываемом новым флебовирусом.

Список литературы

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Problems of Virology. 2017; 62: 60-65

Severe fever with thrombocytopenia syndrome: the disease, caused by the novel phlebovirus

Sizikova T. E., Lebedev V. N., Pantukhov V. B., Borisevich S. V.

https://doi.org/10.18821/0507-4088-2017-62-2-60-65

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a new virus (SFTS virus) reported to be endemic to central and northeastern parts of China. SFTS virus, which is classified into the genus Phlebovirus (the Bunyaviridae family), is suspected to be a tick-borne virus owing to evidence in two species of ticks: Haemaphysalis longicornis and Rhipicephalus microplus. SFTS virus is detected among many species of domestic animals in China. The clinical symptoms of SFTS include fever, thrombocytopenia, leucocytopenia, gastrointestinal symptoms, neural symptoms, bleeding tendency. The fatality rate of SFTS is 6-30%. Person-to-person transmission of SFTS virus is possible through blood contact. Clinical and epidemiological studies of SFTS, the cases of SFTS outside China, person-to-person transmission of SFTS virus, evolutionary and molecular analysis of the emergent SFTS virus, and risk assessment of human infection with a novel phlebovirus are considered in this review.

References

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3. Lam T.T., Liu W., Bowden T.A., Cui N., Zhuang L., Liu K. et al. Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus. Epidemics. 2013; 5 (1): 1-10.

5. Chen H., Hu K., Zou J., Xiao J. A cluster of cases of human-tohuman transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int. J. Infect. Dis. 2013; 17 (3): 206-8.

6. Qu B., Qi X., Wu X., Liang M., Li C., Cardona C.J. et al. Suppression of the interferon and NF-kB responses by severe fever with thrombocytopenia syndrome virus. J. Virol. 2012; 86 (16): 8388-401.

7. Kim K.H., Yi J., Kim G., Choi S.J., Jun K.I., Kim N.H. et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg. Infect. Dis. 2013; 19 (11): 1892-4.

9. Ding F., Zhang W., Wang L., Hu W., Soares Magalhaes R.J., Sun H. et al. Epidemiologic features of severe fever with thrombocytopenia syndrome in China, 2011-2012. Clin. Infect. Dis. 2015; 56 (11): 1682-3.

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12. Zhang Y.Z., Zhou D.J., Qin X.C., Tian J.H., Xiong Y., Wang J.B. et al. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J. Virol. 2012; 86 (5): 2864-8.

13. Lee K.H., Medlock J.M., Heo S.T. Severe fever with thrombocytopenia syndrome virus, Crimean-Congo hemorrhagic fever virus, and migratory birds. J. Bacteriol. Virol. 2013; 43 (4): 235-43.

15. Zhao L., Zhai S., Wen H., Cui F., Chi Y., Wang L. et al. Severe fever with thrombocytopenia syndrome virus, Shandong province, China. Emerg. Infect. Dis. 2012; 18 (6): 963-5.

20. Liu Y., Li Q., Hu W., Wu J., Wang Y., Mei L. et al. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis. 2012; 12 (2): 156-60.

Острая лихорадка с тромбоцитопеническим синдромом: заболевание, вызываемое новым флебовирусом

Аннотация

Severe fever with thrombocytopenia syndrome: the disease, caused by the novel phlebovirus

Abstract

События