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Вопросы вирусологии. 2016; 61: 39-41

Цитокины при инфекции, вызванной вирусом иммунодефицита человека 1-го типа (ВИЧ-1)

Селимова Л. М., Калнина Л. Б., Серебровская Л. В., Иванова Л. А., Гуляева А. Н., Носик Д. Н.

https://doi.org/10.18821/0507-4088-2016-61-1-39-41

Аннотация

В работе изучен уровень провоспалительных (ИЛ-1β, ИФН-γ, ФНО-α, ИЛ-2) и противовоспалительных (ИЛ-4 и ИЛ-10) цитокинов в плазме ВИЧ-инфицированных пациентов, не получающих и получающих высокоактивную антиретровирусную терапию (ВААРТ). ИФН-γ в двух группах пациентов обнаруживали в 94% образцов, ФНО-α – в 88% и ИЛ-2 – в 38% образцов без лечения и в 12 и 30% образцов с ВААРТ соответственно. Обнаружена положительная корреляция между уровнем вирусной нагрузки и количеством ИФН-γ (rs = 0,13) и отрицательная корреляция (rs = -0,242) - у пациентов с ВААРТ и без нее соответственно. У 31% пациентов без лечения наблюдалась косекреция 3 цитокинов (ИФН-γ, ФНО-α и ИЛ-2), у 35% – 2 цитокинов (ИФН-γ, ФНО-α). С ВААРТ у 20% пациентов обнаружена косекреция 3 цитокинов (ИФН-γ, ФНО-α и ИЛ-2) и у 10% - косекреция ИФН-γ и ИЛ-2. Более высокий процент косекреции провоспалительных цитокинов, обнаруженный в плазме пациентов без ВААРТ с продолжительностью инфекции от 6 лет, позволяет предположить, что благодаря этому их иммунная система может сдерживать быстрое прогрессирование болезни.
Список литературы

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8. Zhou J., Sirisanthana T., Kiertiburanakul S., Chen Y.M., Han N., Lim P.L. et al. Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database. BMC Infect. Dis. 2010; 10: 361–70.

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Problems of Virology. 2016; 61: 39-41

Cytokines during the human immunodeficiency virus infection type 1(HIV-1)

Selimova L. M., Kalnina L. B., Serebrovskaya L. V., Ivanova L. A., Gulyaeva A. N., Nosik D. N.

https://doi.org/10.18821/0507-4088-2016-61-1-39-41

Abstract

In this work the proinflammatory (IL-1β, IFN-γ, TNF-α, IL-2) and anti-inflammatory (IL-4, IL-10) plasma cytokine levels were evaluated in HIV-infected patients with or without antiretroviral treatment (ART). IFN-γ was detected in 94% samples with and without art, TNF-α in 88% and il-2 in 38% samples without ART, as well as in 12% and 30% samples with ART, respectively. Positive correlation was detected between viral RNA and IFN-γ levels (rs = 0.13) and negative correlation (rs = –0.242) in the patients without or with ART. Cosecretion of three cytokines (IFN-γ, TNF-α, IL-2) was detected in 31% samples and two cytokines (IFN-γ, TNF-α) in 35% samples of persons without ART. Cosecretion of three cytokines (IFN-γ, TNF-α, IL-2) was detected in 20% samples with ART; cosecretion of IFN-γ and IL-2 was detected in 10% samples. The higher percentage of the proinflammatory cytokines with cosecretion was detected in plasma HIV-infected patients without ART in the course of 6 and more years, which suggests that their immune system is able to provide disease control.
References

1. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989; 7: 145–73.

2. Reuter M.A., Pombo C., Betts M.R. Cytokine production and dysregulation in HIV pathogenesis: Lessons for development of therapeutics and vaccines. Cytokine Growth Factor Rev. 2012; 23(4–5): 181–91.

3. Wherry E.J., Ha S.J., Kaech S.M., Haining W.N., Sarkar S., Kalia V. et al. Molecular signature of CD8 + T cell exhaustion during chronic viral infection. Immunity. 2007; 27(4): 670–84.

4. Clerici M., Shearer G.M. A TH1 → TH2 switch is a critical step in the etiology of HIV infection. Immunol. Today. 1993; 14(3): 107–11.

5. Wilson E.B., Brooks D.G. The role of IL-10 in regulating immunity to persistent viral infections. Curr. Top. Microbiol. Immunol. 2011; 350: 39–65.

6. Moore K.W., de Waal Malefyt R., Coffman R.L., O’Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001; 19: 683–765.

7. Dinarello C.A. The Interleukin-1 family: 10 years of discovery. FASEB J. 1994; 8(15): 1314–25.

8. Zhou J., Sirisanthana T., Kiertiburanakul S., Chen Y.M., Han N., Lim P.L. et al. Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database. BMC Infect. Dis. 2010; 10: 361–70.

9. Pokrovskii V.V., red. VICh-infektsiya i SPID: Klinicheskie rekomendatsii. 2-e izd. M.: Meditsina; 2009.

10. Shaw J., Kaplan B., Paetkau V., Pilarski L.M., Delovitch T.L., McKenzie I. F. Cellular origins of co-stimulator (IL-2) and its activity in cytotoxic T lymphocyte responses. J. Immunol. 1980; 124 (5): 2231–9.

11. Farrar J.J., Mizel S.B., Fuller-Farrar J., Farrar W.L., Hilfiker M.L. Macrophage independent activation of helper T cells. I. Production of interleukin-2. J. Immunol. 1980; 125 (2): 793–8.

12. Nosik N.N. Tsitokiny pri virusnoi infektsii. Voprosy virusologii. 2000; 45(1): 4–10.

13. Guidotti L. G., Chisari F.V. Cytokine-mediated control of viral Infections. Virology. 2000; 273(2): 221–7.

14. Kannanganat S., Kapogiannis B.G., Ibegbu C., Chennareddi L., Goepfert P., Robinson H.L. et al. Human immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines. J. Virol. 2007; 81(21): 12071–6.