Вопросы вирусологии. 2021; 66: 91-102
Обзор кандидатных вакцин для профилактики лихорадки Ласса
https://doi.org/10.36233/0507-4088-33Аннотация
Вирус Ласса (ВЛ) является одним из основных этиологических факторов этиологическим фактором геморрагических лихорадок в мире: по оценкам ВОЗ им ежегодно поражаются от 100 до 300 тыс. человек, а связанная с ВЛ смертность составляет до 10 тыс. в год [1]. Несмотря на то что распространение вызываемого им заболевания – лихорадки Ласса (ЛЛ) – в основном ограничено западноафриканскими странами (Сьерра-Леоне, Либерия, Гвинея и Нигерия), исторически документированы завозные случаи в Европе, Соединённых Штатах Америки (США), Канаде, Японии и Израиле [2]. В 2017 г. ВОЗ включила ВЛ в список приоритетных патогенов, в отношении которых необходимы проведение ускоренных исследований, создание вакцинных препаратов, а также средств для терапии и диагностики инфекций, возбудителями которых они являются [3]. В данном обзоре рассмотрены основные технологические платформы, используемые при разработке вакцин против ЛЛ.
Список литературы
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Problems of Virology. 2021; 66: 91-102
Review of candidate vaccines for the prevention of Lassa fever
https://doi.org/10.36233/0507-4088-33Abstract
The Lassa virus one of the main etiological agent of hemorrhagic fevers in the world: according to WHO estimates, it affects 100,000 to 300,000 people annually, which results in up to 10,000 deaths [1]. Although expansion of Lassa fever caused by this pathogen is mostly limited to the West African countries: Sierra Leone, Liberia, Guinea and Nigeria, imported cases have been historically documented in Europe, the United States of America (USA), Canada, Japan, and Israel [2]. In 2017, WHO included the Lassa virus in the list of priority pathogens in need of accelerated research, development of vaccines, therapeutic agents and diagnostic tools regarding infections they cause [3]. This review describes main technological platforms used for the development of vaccines for the prevention of Lassa fever.
References
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7. Okokhere P., Colubri A., Azubike C., Iruolagbe C., Osazuwa O., Tabrizi S., et al. Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: an observational cohort study. Lancet Infect. Dis. 2019; 18(6): 684–95. https://doi.org/10.1016/s1473-3099(18)30121-x.
8. Asogun D.A., Günther S., Akpede G.O., Ihekweazu C., Zumla A. Lassa fever: epidemiology, clinical features, diagnosis, management and prevention. Infect. Dis. Clin. North Am. 2019; 33(4): 933–51. https://doi.org/10.1016/j.idc.2019.08.002.
9. Mateer E.J., Huang C., Shehu N.Y., Paessler S. Lassa fever-induced sensorineural hearing loss: A neglected public health and social burden. PLoS Negl. Trop. Dis. 2018; 12(2): e0006187. https://doi.org/10.1371/journal.pntd.0006187.
10. Okogbenin S., Okoeguale J., Akpede G., Colubri A., Barnes K.G., Mehta S., et al. Retrospective cohort study of Lassa fever in pregnancy, Southern Nigeria. Emerg. Infect. Dis. 2019; 25(8): 1495–500. https://doi.org/10.3201/eid2508.181299.
11. Buba M.I., Dalhat M.M., Nguku P.M., Waziri N., Mohammad J.O., Bomoi I.M., et al. Mortality among confirmed Lassa fever cases during the 2015–2016 outbreak in Nigeria. Am. J. Public Health. 2018; 108(2): 262–4. https://doi.org/10.2105/ajph.2017.304186.
12. NCDC. Lassa fever Situation Report. 2020. Available at: https://ncdc.gov.ng/themes/common/files/sitreps/15a12399a0aa98330e56dabd49ccefb8.pdf (accessed December 15, 2020).
13. Radoshitzky S.R., Buchmeier M.J., Charrel R.N., Clegg J.C.S., Gonzalez J.J., Günther S., et al. ICTV virus taxonomy profile: Arenaviridae. J. Gen. Virol. 2019; 100(8): 1200–1. https://doi.org/10.1099/jgv.0.001280.
14. Klitting R., Mehta S.B., Oguzie J.U., Oluniyi P.E., Pauthner M.G., Siddle K.J., et al. Lassa Virus Genetics. Curr. Top. Microbiol. Immunol. 2020, online ahead of print. https://doi.org/10.1007/82_2020_212.
15. Zinzula L., Tramontano E. Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: Hide, mask, hit. Antiviral Res. 2013; 100(3): 615–35. https://doi.org/10.1016/j.antiviral.2013.10.002.
16. Lenz O., ter Meulen J., Klenk H.D., Seidah N.G., Garten W. The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proc. Natl. Acad. Sci. USA. 2001; 98(22): 12701–5. https://doi.org/10.1073/pnas.221447598.
17. Knipe D.M., Howley P. Fields Virology. New York: Lippincott Williams & Wilkins; 2013.
18. Mateo M., Reynard S., Carnec X., Journeaux A., Baillet N., Schaeffer J., et al. Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot. Sci. Transl. Med. 2019; 11(512): eaaw3163. https://doi.org/10.1126/scitranslmed.aaw3163.
19. Whitmer S.L.M., Strecker T., Cadar D., Dienes H.P., Faber K., Patel K., et al. New lineage of Lassa virus, Togo, 2016. Emerg. Infect. Dis. 2018; 24(3): 599–602. https://doi.org/10.3201/eid2403.171905.
20. McLay L., Liang Y., Ly H. Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections. J. Gen. Virol. 2014; 95(Pt. 1): 1–15. https://doi.org/10.1099/vir.0.057000-0.
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